COVID-19’s Vaccine Rejection: Lesson Learned To Preserving Health Security In Indonesia

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Reinpal Falefi
Hikmat Zakky Almubaraq
Susilawati Susilawati


Background: Indonesia is a country with low COVID-19 vaccination coverage from 2020 through 2021. Different sociodemographic conditions determine the success of vaccination in suppressing the transmission of COVID-19. This systematic review aims to identify the reasons for the refusal of the COVID-19 vaccine among the general and vulnerable communities in Indonesia.

Methods: This study uses a systematic review method using PubMed and Google Scholar. The keywords used are COVID-19 vaccine, acceptance, determinant, and Indonesia. The article, which was specifically researched, presents the acceptance of the COVID-19 vaccine in Indonesia only in 2020 and 2021. Elicit information from found articles to form conclusions for each article.

Results: Based on 12 studies, the main causes of the rejection of the COVID-19 vaccine in Indonesia are knowledge and negative attitudes. In the aspect of knowledge, three things become problems, namely fear of the side effects of vaccination, doubts about the effectiveness of vaccines, and doubts about vaccine safety. Negative attitudes are influenced by propaganda and conspiracies.

Conclusion: The general population and vulnerable people in Indonesia are more likely to reject the COVID-19 vaccine, so the target for mass vaccination is not achieved, the main reasons being knowledge and perception. Control strategies and invitations for specific COVID-19 vaccinations are critical in order to get the general public and vulnerable populations to participate in vaccination activities. 

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How to Cite
Falefi, R., Almubaraq, H. Z., & Susilawati, S. (2022). COVID-19’s Vaccine Rejection: Lesson Learned To Preserving Health Security In Indonesia. Interest : Jurnal Ilmu Kesehatan, 169–181.


Arina, E. (2020). Strategi dan Tantangan dalam Meningkatkan Cakupan Vaksinasi COVID-19 untuk Herd Immunity. Jurnal Bagus, 02(01), 402–406.

Arumsari, W., Desty, R. T., Eko, W., & Kusumo, G. (2021). Indonesian Journal of Health Community Gambaran Penerimaan Vaksin COVID-19 di Kota Semarang Info Articles. Indonesian Journal of Health Community 2, 2(1), 35-45-undefined.

Arumsari, W., Desty, R. T., & Kusumo, W. E. G. (2021). Gambaran Penerimaan Vaksin COVID-19 di Kota Semarang. Indonesian Journal of Health Community; Vol 2 No 1 (2021): Artikel Bulan Juni.

Bhutta, Z. A., Basnyat, B., Saha, S., & Laxminarayan, R. (2020). Covid-19 risks and response in South Asia. The BMJ, 368(March), 1–2.

Bollyky, T., & Brown, C. P. (2020). The Tragedy of Vaccine Nationalism. Foreign Affairs, 99(March), Jul 27.

Chhetri, J. K., Chan, P., Arai, H., Park, S. C., Sriyani Gunaratne, P., Setiati, S., & Assantachai, P. (2020). Prevention of COVID-19 in Older Adults: A Brief Guidance from the International Association for Gerontology and Geriatrics (IAGG) Asia/Oceania Region. Journal of Nutrition, Health and Aging, 24(5), 471–472.

Cisłak, A., Pyrczak, M., Mikiewicz, A., & Cichocka, A. (2020). Brexit and Polexit: Collective narcissism is associated with support for leaving the European Union. Social Psychological Bulletin, 15(1).

COVID-19 Handling Task Force. (2021). 3 Reasons for Booster Vaccines According to WHO. Satgas COVID-19.

Cummings, C. L., Rosenthal, S., & Kong, W. Y. (2021). Secondary Risk Theory: Validation of a Novel Model of Protection Motivation. Risk Analysis, 41(1), 204–220.

Di Gennaro, F., Pizzol, D., Marotta, C., Antunes, M., Racalbuto, V., Veronese, N., & Smith, L. (2020). Coronavirus diseases (COVID-19) current status and future perspectives: A narrative review. International Journal of Environmental Research and Public Health, 17(8).

Dinleyici, E. C., Borrow, R., Safadi, M. A. P., van Damme, P., & Munoz, F. M. (2021). Vaccines and routine immunization strategies during the COVID-19 pandemic. Human Vaccines and Immunotherapeutics, 17(2), 400–407.

Duan, Y., Shi, J., Wang, Z., Zhou, S., Jin, Y., & Zheng, Z.-J. (2021). Disparities in COVID-19 vaccination among low-, middle-, and high-income countries: the mediating role of vaccination policy. Vaccines, 9(8), 905.

Dubé, E., Gagnon, D., Ouakki, M., Bettinger, J. A., Guay, M., Halperin, S., Wilson, K., Graham, J., Witteman, H. O., MacDonald, S., Fisher, W., Monnais, L., Tran, D., Gagneur, A., Guichon, J., Saini, V., Heffernan, J. M., Meyer, S., Driedger, S. M., … MacDougall, H. (2016). Understanding Vaccine Hesitancy in Canada: Results of a Consultation Study by the Canadian Immunization Research Network. PLOS ONE, 11(6), e0156118.

Febriyanti, N., Choliq, M. I., & Mukti, A. W. (2021). Hubungan Tingkat Pengetahuan dan Kesediaan Vaksinasi Covid-19 Pada Warga Kelurahan Dukuh Menanggal Kota Surabaya. In Seminar Nasional Hasil Riset dan Pengabdian (Vol. 3, pp. 1–7). file:///C:/Users/USER/AppData/Local/Temp/168-Article Text-499-1-10-20210424.pdf

Forman, R., Shah, S., Jeurissen, P., Jit, M., & Mossialos, E. (2021). COVID-19 vaccine challenges: What have we learned so far and what remains to be done? Health Policy, 125(5), 553–567.

Handayani, L. V., Azka, N., Wijayanti, S. N., Aini, R. N., Rusmiati, & Santoso, A. P. A. (2021). Pengaruh Komunikasi tentang Vaksin Sinovac Terhadap Kesadaran Masyarakat di Desa Jembrak Kabupaten Semarang. MEDFARM: Jurnal Farmasi Dan Kesehatan, 10(1), 18–27.

Harapan, H., Wagner, A. L., Yufika, A., Winardi, W., Anwar, S., Gan, A. K., Setiawan, A. M., Rajamoorthy, Y., Sofyan, H., & Mudatsir, M. (2020). Acceptance of a COVID-19 Vaccine in Southeast Asia: A Cross-Sectional Study in Indonesia. In Frontiers in Public Health (Vol. 8).

Harun, A., & Ananda, D. P. (2021). Analysis of Public Opinion Sentiment About Covid-19 Vaccination in Indonesia Using Naïve Bayes and Decission Tree Analisa Sentimen Opini Publik Tentang Vaksinasi Covid-19 di Indonesia Menggunakan Naïve Bayes dan Decission Tree. In Indonesia Journal of Machine Learning and Computer Science (Vol. 1, Issue April, pp. 58–63).

Huang, J., Huang, H., Wang, D., Wang, C., & Wang, Y. (2020). Immunological strategies against spike protein: Neutralizing antibodies and vaccine development for COVID‐19. Clinical and Translational Medicine, 10(6), 1–6.

Ichsan, D. S., Hafid, F., Ramadhan, K., & Taqwin, T. (2021). Determinan Kesediaan Masyarakat menerima Vaksinasi Covid-19 di Sulawesi Tengah. In Poltekita : Jurnal Ilmu Kesehatan (Vol. 15, Issue 1, pp. 1–11).

Indonesian Ministry of Health. (2022). National COVID-19 Vaccination (Data updated 20 October 2022 at 18.00 WIB). Kemenkes RI.

Kafrawi, R. M. (2022). Implikasi Sertifikat Vaksin Coronavirus Disease (COVID-19) Terhadap Pelayanan Publik. Jurnal Hukum Dan Etika Kesehatan, 1(1), 134–146.

Lal, A., Erondu, N. A., Heymann, D. L., Gitahi, G., & Yates, R. (2021). Fragmented health systems in COVID-19: rectifying the misalignment between global health security and universal health coverage. The Lancet, 397(10268), 61–67.

Lazarus, J. V., Ratzan, S. C., Palayew, A., Gostin, L. O., Larson, H. J., Rabin, K., Kimball, S., & El-Mohandes, A. (2021). A global survey of potential acceptance of a COVID-19 vaccine. Nature Medicine, 27(2), 225–228.

Leng, A., Maitland, E., Wang, S., Nicholas, S., Liu, R., & Wang, J. (2021). Individual preferences for COVID-19 vaccination in China. Vaccine, 39(2), 247–254.

Lim, W. S., Liang, C. K., Assantachai, P., Auyeung, T. W., Kang, L., Lee, W. J., Lim, J. Y., Sugimoto, K., Akishita, M., Chia, S. L., Chou, M. Y., Ding, Y. Y., Iijima, K., Jang, H. C., Kawashima, S., Kim, M., Kojima, T., Kuzuya, M., Lee, J., … Arai, H. (2020). COVID-19 and older people in Asia: Asian Working Group for Sarcopenia calls to actions. Geriatrics and Gerontology International, 20(6), 547–558.

Lushington, G. H. (2020). Perspective on the COVID-19 Coronavirus Outbreak. Combinatorial Chemistry & High Throughput Screening, 23(2), 90–91.

Ma’rifati, L. (2021). Faktor-Faktor Penerimaan Vaksin Covid-19 Pada Masyarakat Kota Salatiga Ditinjau dari Teori Health Belief Model. Diponegoro University.

Miller, B. L. (2020). Science Denial and COVID Conspiracy Theories Potential Neurological Mechanisms and Possible Responses. JAMA, 324(22), 2255–2256.

Ministry of Health Republic of Indonesia. (2020). COVID-19 Vaccine Acceptance Survey in Indonesia. Journal of Materials Processing Technology, 1(1), 1–8.

Muchammadun, M., Rachmad, S. H., Handiyatmo, D., Tantriana, A., Rumanitha, E., & Amrulloh, Z. (2021). Peran Tokoh Agama dalam Menangani Penyebaran Covid-19. Religious: Jurnal Studi Agama-Agama Dan Lintas Budaya, 5(1), 87–96.

Nadya, V. (2021). Faktor-Faktor yang Berhubungan dengan Penerimaan Masyarakat Terhadap Vaksinasi Covid-19 di Kota Padang Tahun 2021. Andalas University.

Nguyen, K. H., Srivastav, A., Razzaghi, H., Williams, W., Lindley, M. C., Jorgensen, C., Abad, N., & Singleton, J. A. (2021). COVID‐19 vaccination intent, perceptions, and reasons for not vaccinating among groups prioritized for early vaccination — United States, September and December 2020. American Journal of Transplantation, 21(4), 1650–1656.

Omer, S. B., Yildirim, I., & Forman, H. P. (2020). Herd Immunity and Implications for SARS-CoV-2 Control. JAMA, 324(20), 2095.

Paul, E., Steptoe, A., & Fancourt, D. (2021). Attitudes towards vaccines and intention to vaccinate against COVID-19: Implications for public health communications. The Lancet Regional Health - Europe, 1, 100012.

Piltch-Loeb, R., Savoia, E., Goldberg, B., Hughes, B., Verhey, T., Kayyem, J., Miller-Idriss, C., & Testa, M. (2021). Examining the effect of information channel on COVID-19 vaccine acceptance. PLoS ONE, 16(5 May), 1–14.

Porat, T., Nyrup, R., Calvo, R. A., Paudyal, P., & Ford, E. (2020). Public Health and Risk Communication During COVID-19—Enhancing Psychological Needs to Promote Sustainable Behavior Change. Frontiers in Public Health, 8(October).

Rachman, F. F., & Pramana, S. (2020). Analisis Sentimen Pro dan Kontra Masyarakat Indonesia tentang Vaksin COVID-19 pada Media Sosial Twitter. In Health Information Management Journal (Vol. 8, Issue 2, pp. 100–109).

Sahara, W. (2021). UPDATE: Sebaran 201 Zona Merah Covid-19 di Indonesia, DKI Jakarta Tidak Termasuk. Kompas.

Saied, S. M., Saied, E. M., Kabbash, I. A., & Abdo, S. A. E. F. (2021). Vaccine hesitancy: Beliefs and barriers associated with COVID-19 vaccination among Egyptian medical students. Journal of Medical Virology, 93(7), 4280–4291.

Sallam, M., Dababseh, D., Eid, H., Al-Mahzoum, K., Al-Haidar, A., Taim, D., Yaseen, A., Ababneh, N. A., Bakri, F. G., & Mahafzah, A. (2021). High rates of covid-19 vaccine hesitancy and its association with conspiracy beliefs: A study in jordan and kuwait among other arab countries. Vaccines, 9(1), 1–16.

Sauer, M. A., Truelove, S., Gerste, A. K., & Limaye, R. J. (2021). A failure to communicate? how public messaging has strained the COVID-19 response in the united states. Health Security, 19(1), 65–74.

Schaffer Deroo, S., Pudalov, N. J., & Fu, L. Y. (2020). Planning for a COVID-19 Vaccination Program. JAMA - Journal of the American Medical Association, 323(24), 2458–2459.

Schoch-Spana, M., Brunson, E. K., Long, R., Ruth, A., Ravi, S. J., Trotochaud, M., Borio, L., Brewer, J., Buccina, J., Connell, N., Hall, L. L., Kass, N., Kirkland, A., Koonin, L., Larson, H., Lu, B. F., Omer, S. B., Orenstein, W. A., Poland, G. A., … White, A. (2020). The public’s role in COVID-19 vaccination: Human-centered recommendations to enhance pandemic vaccine awareness, access, and acceptance in the United States. Vaccine, xxxx.

Susilo, D., Putranto, T. D., & Navarro, C. J. S. (2021). 9 Performance of Indonesian Ministry of Health in Overcoming Hoax About Vaccination Amid the COVID-19 Pandemic on Social Media. Nyimak: Journal of Communication, 5(1), 151.

van Prooijen, J. W., & van Vugt, M. (2018). Conspiracy Theories: Evolved Functions and Psychological Mechanisms. Perspectives on Psychological Science, 13(6), 770–788.

Wea, L. D., Mera, E., Suriaty, M. I., & Nasvia, D. (2022). Penerapan Visualisasi Tentang Vaksin Covid 19 Menggunakan Pendekatan Bahasa Daerah Manggarai Sebagai Upaya Meningkatkan Kesiapan Masyarakat Menerima Vaksin. JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM), 5(2), 472–478.

Wilda, S. (2021). Faktor-Faktor yang Berhubungan dengan Niat Masyarakat dalam Mengikuti Vaksinasi Corona Virus Disease (COVID-19) di Kecamatan Padang Gelugur Kabupaten Pasaman Provinsi Sumatera Barat Tahun 2021. Universitas Andalas.

Wirawan, G. B. S., Mahardani, P. N. T. Y., Cahyani, M. R. K., Laksmi, N. L. P. S. P., & Januraga, P. P. (2021). Conspiracy beliefs and trust as determinants of COVID-19 vaccine acceptance in Bali, Indonesia: Cross-sectional study. Personality and Individual Differences, 180(1–3).

Zulfa, I. M., & Yunitasari, F. D. (2021). Edukasi Generasi Muda Siap Vaksinasi COVID-19. Asta, 1(2), 100–112.