Formulation Of Topical Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Of Vitamin D3
Main Article Content
Background: In the last few decades, there has been a significant increase in customers’ interest in skin care, including anti-aging. One of the skin care substances, vitamin D3, has a positive impact on the skin, such as the keratinocyte differentiation effect to maintain the skin barrier and the hydration effect to keep the skin moist. Vitamin D3 has a high lipophilicity, so it is considered ideal to formulate in the self-nano emulsifying drug delivery system (SNEDDS). The higher solubility of vitamin D3 in the SNEDDS oil component could improve its penetration through the skin. The SNEDDS is a primary dosage form that can be entrapped in semisolid base dosage forms, such as cream, lotion, or gel. SNEDDS vitamin D3 needs to be optimized to obtain the appropriate composition of the components: oil, surfactant, and co-surfactant.
Methods: The D-Optimal Mixture method using Design Expert 10 software had been chosen as an optimization tool for SNEDDS vitamin D3.
Results: The composition of the optimum formula was obtained as follows: 1.0351 g Miglyol 812 N; 3.0637 g Tween 80 and 0.9011 g PEG 400. The optimum formula has a particle size of 32.62 nm ± 1.80 nm and a polydispersity index of 0.31 ± 0.03.
Conclusion: The release test was carried out with the help of a Franz diffusion cell instrument, a cellophane membrane, and phosphate-buffered saline pH 7.4 containing 0.5% Tween 80. The cumulative amount of vitamin D3 released per minute (Flux) was 0.10 µg/min.
Abd-Allah, F. I., Dawaba, H. M., & Ahmed, A. M. (2010). Preparation, characterization, and stability studies of piroxicam-loaded microemulsions in topical formulations. Drug Discoveries & Therapeutics, 4(4), 267–275.
Astuti, I. Y. (2018). Optimasi Formula dan Studi Aktivitas Antiinflamasi Self-Nanoemulsifying Drug Delivery System (SNEEDS) Pentagamavunon-0 (PGV-0). Universitas Gadjah Mada.
Bikle, D. D. (2012). Vitamin D and the skin: physiology and pathophysiology. Rev Endocr Metab Disord, 13(1), 3–19.
Clares, B., Calpena, A. C., Parra, A., Abrego, G., Alvarado, H., Fangueiro, J. F., & Souto, E. B. (2014). Nanoemulsions (NEs), liposomes (LPs) and solid lipid nanoparticles (SLNs) for retinyl palmitate: effect on skin permeation. International Journal of Pharmaceutics, 473(1–2), 591–598. https://doi.org/10.1016/j.ijpharm.2014.08.001
Cui, J., Yu, B., Zhao, Y., Zhu, W., Li, H., Lou, H., & Zhai, G. (2009). Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. International Journal of Pharmaceutics, 371(1–2), 148–155. https://doi.org/10.1016/j.ijpharm.2008.12.009
Dobak, J., Grzybowski, J., Liu, F. T., Landon, B., & Dobke, M. (1994). 1,25-Dihydroxyvitamin D3 increases collagen production in dermal fibroblasts. Journal of Dermatological Science, 8(1), 18–24. https://doi.org/10.1016/0923-1811(94)90316-6
Fotaki, N., Brown, W., Kochling, J., Chokshi, H., Miao, H., Tang, K., & Gray, V. (2013). Rationale for selection of dissolution media: three case studies. Dissolution Technologies, 20(3), 6–13. https://doi.org/10.14227/DT200313P6
Guttoff, M., Saberi, A. H., & Mcclements, D. J. (2015). Formation of vitamin D nanoemulsion-based delivery systems by spontaneous emulsification: factors affecting particle size and stability. Food Chemistry, 171, 117–122. https://doi.org/10.1016/j.foodchem.2014.08.087
Handayani, S. A., Purwanti, T., & Erawati, T. (2012). Pelepasan Na-Diklofenak sistem niosom span 20-kolesterol dalam basis gel HPMC. Pharmascientia, 1(2), 21–28.
Lin, T. K., Zhong, L., & Santiago, J. L. (2018). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1). https://doi.org/10.3390/ijms19010070
Mohsin, K., Shahba, A. A., & Alanazi, F. K. (2012). Lipid based self emulsifying formulations for poorly water soluble drugs: an excellent opportunity. Indian Journal of Pharmaceutical Education and Research, 46(2), 88–96.
Mostafa, W. Z., & Hegazy, R. A. (2015). Vitamin D and the skin: Focus on a complex relationship: a review. J Adv Res, 6(6), 793–804.
Philips, N., Portillo-Esnaola, M., Samuel, P., Gallego-Rentero, M., Keller, T., & Franco, J. (2022). Anti-aging and anti-carcinogenic effects of 1α, 25-dihyroxyvitamin D3 on skin. Plastic and Aesthetic Research. https://doi.org/10.20517/2347-9264.2021.83
Piotrowska, A., Wierzbicka, J., & Zmijewski, M. A. (2016). Vitamin D in the skin physiology and pathology. Acta Biochimica Polonica, 63(1), 17–29. https://doi.org/10.18388/abp.2015_1104
Ramos-e-Silva, M., Celem, L. R., Ramos-e-Silva, S., & Fucci-da-Costa, A. P. (2013). Anti-aging cosmetics: facts and controversies. Clinics in Dermatology, 31(6), 750–758. https://doi.org/10.1016/j.clindermatol.2013.05.013
Rehman, F. U., Shah, K. U., Shah, S. U., Khan, I. U., Khan, G. M., & Khan, A. (2017). From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opinion on Drug Delivery, 14(11), 1325–1340. https://doi.org/10.1080/17425247.2016.1218462
Xu, X., Khan, M. A., & Burgess, D. J. (2012). A two-stage reverse dialysis in vitro dissolution testing method for passive targeted liposomes. International Journal of Pharmaceutics, 426(1–2), 211–218. https://doi.org/10.1016/j.ijpharm.2012.01.030