Analysis Of Severity Factors In COVID-19 Patients With Comorbid Diabetes Melitus

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Sandi Alfa Wiga Arsa
Erni Setiyorini
Thatit Nurmawati
Anita Rahmawati
Eko Wiyono


Background: Patients infected with the SARS-CoV2/COVID-19 virus and comorbid diabetes mellitus type 2 will experience a worsening of their condition, resulting in increased levels of inflammatory mediators in the blood, including lipopolysaccharide, inflammatory cytokines, and toxic metabolites that cause pulmonary fibrosis. This study aimed to determine the factors associated with the severity of COVID patients with comorbid Diabetes Mellitus Type 2.

Methods: A qualitative study, a cohort with secondary data from April to August 2021, sampling 142 medical records. Independent Variables are Age, Gender, Blood Glucose, Oxygen, Saturation (SPO2), D-Dimer Value, Other Comorbidities.

Results: The results of the selection of bivariate analysis showed that the variables that had no relationship were age (p = 0.262), gender (p = 0.340), and other co-morbidities (p = 0.962), while those having a relationship following the multivariate test were random blood sugar variables (p = 0.031), SPO2 oxygen saturation (p = 0.000), and d-dimer (p = 0.034). The multivariate results using the linear logistic regression test showed that the results of variables related to the severity of COVID-19 and co-morbid diabetes mellitus were blood sugar (p = 0.417), SPO2 (p = 0.095), and D-dimer (p = 0.890), which had no partial effect on the level of severity, but together these three variables equally affect the level of severity.

Conclusion: SAR-CoV2 patients with comorbid Type 2 DM, accompanied by decreased SPO2, increased d-dimer values, increased random blood sugar, with a predictive rate of 93.7%, experienced severe severity.

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Alfa Wiga Arsa, S. ., Setiyorini, E. ., Nurmawati, T. ., Rahmawati, A. ., & Wiyono, E. (2022). Analysis Of Severity Factors In COVID-19 Patients With Comorbid Diabetes Melitus. Interest : Jurnal Ilmu Kesehatan, 243–253.


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