Assessment of “Proning” Nursing Intervention to Increase ROX Index in COVID-19 Patients: A Literature Review

Main Article Content

Martono Martono
Siti Khadijah
Pradita Ayu Fernanda

Abstract

Background: COVID-19 has become a global crisis that has created public health problems. The impact of COVID-19 infection primarily affects the respiratory tract. The most prominent impairments in COVID-19 infection include difficulty breathing and decreased blood oxygen saturation. This review aims to identify available literature related to the effects of proning techniques on improving respiratory rate and oxygenation (ROX) indices, namely SPO2 and PaO2/FiO2 fractions, in patients with acute respiratory distress syndrome (ARDS) due to COVID-19. 

Methods: A literature review design was employed. An online search strategy was conducted using major electronic databases, including Scopus, PubMed, Science Direct, ProQuest, and Google Scholar. This review design used the Preferred Reporting Items for Systemic Review and Meta-Analysis (PRISMA) Guidelines. The literature sources reviewed ranged from 2020 to 2025. Ten articles met the criteria and were reviewed. 

Results: A total of 387 articles met the screening criteria: 159 articles were identified after screening for duplication, 25 articles met the criteria for full-text review and eligibility, and 15 articles were excluded due to study design and irrelevant results. Ten articles met the criteria and were reviewed.

Conclusion: Proning is the use of a prone position that can improve the body's oxygenation adequacy index, both ROX with the SpO₂ indicator and the PaO₂/FiO₂ ratio, and these findings highlight the health practice that healthcare professionals play a key role in assessing oxygenation status, safely applying prone positioning, and closely monitoring patient responses to optimize respiratory outcomes.

Article Details

How to Cite
Assessment of “Proning” Nursing Intervention to Increase ROX Index in COVID-19 Patients: A Literature Review. (2025). Interest : Jurnal Ilmu Kesehatan, 14(2), 117-129. https://doi.org/10.37341/interest.v14i2.758
Section
Articles

How to Cite

Assessment of “Proning” Nursing Intervention to Increase ROX Index in COVID-19 Patients: A Literature Review. (2025). Interest : Jurnal Ilmu Kesehatan, 14(2), 117-129. https://doi.org/10.37341/interest.v14i2.758

References

AACN. (2023). Manual prone positioning in adult: Reducing the risk of harm through. Critical care Nurse, 43(1), 59–66.

Anand, S., Baishya, M., Singh, A., & Khanna, P. (2021). Trends in anaesthesia and critical care effect of awake prone positioning in COVID-19 patients- A systematic review. Trends in Anaesthesia and Critical Care, 36, 17–22. https://doi.org/https://doi.org/10.1016/j.tacc.2020.09.008

Andriananja, V., Rakotomijoro, E., & Andriamizaka, J. (2024). Effect of prone position in severe Covid-19 patients in a referral center : A cohort retrospective study. Advances in Infectious Diseases, 14, 248–259. https://doi.org/10.4236/aid.2024.141019

Bidarian-Moniri;, A., Nilsson;, M., Rasmusson;, L., Attia;, J., & Ejnell, H. (2015). The effect of the prone sleeping position on obstructive sleep apnoea. Acta Oto Laryngologica, 135(1), 79–84. https://doi.org/10.3109/00016489.2014.962183

Chakraborty, R., Gupta, N., & Patel, S. (2023). Prone positioning: Current nursing considerations, complications, and monitoring strategies in ARDS. Journal of Critical Care Nursing, 38(4), 211–220.

Chua, E. X., Mohd, S., Syed, I., Zahir, M., Ng, K. T., Teoh, W. Y., Hasan, M. S., Rahayu, S., Ruslan, B., & Abosamak, M. F. (2021). Effect of prone versus supine position in COVID-19 patients : A systematic review and meta-analysis. Journal of Clinical Anesthesia, 74, 110406. https://doi.org/10.1016/j.jclinane.2021.110406

Ding, L., Wang, L., Ma, W., & He, H. (2020). Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS : A multi-center prospective cohort study. Critical Care, 24(8), 1–8. https://doi.org/10.1186/s13054-020-2738-5

Fan, E., Brochard, L., & Slutsky, A. S. (2023). Acute respiratory distress syndrome: Updated clinical practice guidelines and evidence-based recommendations. The Lancet Respiratory Medicine, 11(2), 115–130.

Fan, E., Sorbo, L. Del, Goligher, E. C., Hodgson, C. L., Munshi, L., Walkey, A. J., Adhikari, N. K. J., Amato, M. B. P., Branson, R., Brower, R. G., Ferguson, N. D., Gajic, O., Gattinoni, L., Hess, D., Mancebo, J., Meade, M. O., Mcauley, D. F., Pesenti, A., Ranieri, V. M., … Brochard, L. J. (2017). An Official American Thoracic Society/European Society of Intensive Care Medicine/ Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Synd. American Journal of Respiratory and Critical Care Medicine, 195(9), 1253–1263. https://doi.org/DOI: 10.1164/rccm.201703-0548ST

Gattinoni, L., Brusatori, S., Albo, R. D., Maj, R., Velati, M., Zinnato, C., Gattarello, S., Lombardo, F., Fratti, I., Romitti, F., Saager, L., & Camporota, L. (2023). Prone position: How understanding and clinical application of a technique progress with time. Anesthesiology and Perioperative Science, 1(3), 1–17. https://doi.org/DOI: 10.1007/s44254-022-00002-2

Helms, J., Simon, M., & Caso, G. (2023). Prone positioning in COVID-19 and non-COVID ARDS: Updated safety criteria and patient selection. Critical Care Clinics, 39(1), 45–60.

Işıldak, Y. İ., Aslan, F. E., & Parlak, G. (2023). Determination of the effect of the fowler and prone position on oxygen saturation in patients diagnosed with COVID-19. Clinical and Experimental Health Sciences, 13(1), 159–165. https://doi.org/10.33808/clinexphealthsci.1186086

Islam, M. R., Sohan, M., Roknuzzaman, A. S. M., Islam, M., Shahriar, M., & Bhuiyan, M. A. (2025). Evaluation of SARS-CoV-2 variants after the declaration of end of COVID-19 pandemic: BA.2.86 (Pirola) and EG.5 (Eris) variants as global public health concerns. Health Science Reports, 8(10), e71394.

Jouffroy, R., Darmon, M., Isnard, F., Geri, G., Beurton, A., Fartoukh, M., Tudesq, J., Nemlaghi, S., Demoule, A., Azoulay, E., & Vieillard-baron, A. (2021). Impact of prone position in non-intubated spontaneously breathing patients admitted to the ICU for severe acute respiratory failure due to COVID-19. Journal of Critical Care Journal, 64(Agustus), 199–204. https://doi.org/10.1016/j.jcrc.2021.04.014

Kemenkes. (2022). Situasi Terkini Perkembangan Coronavirus Disease (COVID19). Retrieved 03 December from https://infeksiemerging.kemkes.go.id/situasi-infeksiemerging/situasi-terkini-perkembangan-coronavirus-disease-covid-19-13april-2022

Lee, H. Y., Cho, J., Kwak, N., Choi, S. M., Lee, J., Sik, Y., Lee, C., Yoo, C., Kim, Y. W., & Lee, S. (2020). Improved Oxygenation After Prone Positioning May Be a Predictor of Survival in Patients With Acute Respiratory Distress Syndrome. Critical Care Medicine, 48(12), 1729–1736. https://doi.org/10.1097/CCM.0000000000004611

Liang, H., Deng, Q., Ye, W., Jiang, Z., Zhang, B., & Zhang, J. (2024). Prone position ventilation ‑ induced oxygenation improvement as a valuable predictor of survival in patients with acute respiratory distress syndrome: A retrospective observational study. BMC Pulmonary Medicine, 24(1), 575. https://doi.org/10.1186/s12890-024-03349-3

Manirambona, E., John, O., Olabode, N., Tolutope, O., Oso, A., Eliseo, D., & Prisno, L. (2024). Evolution and implications of SARS‑CoV‑2 variants in the post‑pandemic era. Discover Public Health, 21(16). https://doi.org/https://doi.org/10.1186/s12982-024-00140-x

Manuela, S., Oliveira, R., Marisa, A., Jorge, P., & Silva, V. (2023). Prone position effect in intensive care patients with SARS-COV-2 pneumonia. Open Medicine (Poland), 18(1). https://doi.org/10.1515/med-2023-0735

Mookerjee;, S., Nageshwaran;, V., Old;, T., Oxley;, C., Jordon;, L., Selvan;, M., Wood;, A., Ying;, A., Zhang;, C., Wozniak;, D., Goodhart;, I., Early;, F., Fisk;, M., & Fuld, J. (2022). Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge. ERJ Open Research, 8(1). https://doi.org/10.1183/23120541.00524-2021

Mostafa, H., Mohamed, G., Mashad, E., Zakaria, M., & Mohamed, E. (2023). Comparison of massage and prone position on heart rate and blood oxygen saturation level in preterm neonates hospitalized in neonatal intensive care units. Egypt Pediatric Association, 71(70). https://doi.org/https://doi.org/10.1186/s43054-023-00214-6

Nie, A., Su, X., Dong, M., & Guan, W. (2022). Are nurses prepared to respond to the next infectious disease outbreak? A narrative synthesis. Nursing Open, 9(2), 908–919.

Nurani, I. A., Departement, N., & Nasional, U. (2023). the effect of prone positioning to increase oxygen saturation in Covid-19 patients at Hermina Banyumanik Hospital. Jurnal Kesehatan Dr. Soebandi, 11(1), 52–57. https://doi.org/10.36858/jkds.v11i1.454

Park, J., Lee, H. Y., Lee, J., & Lee, S. M. (2021). Effect of prone positioning on oxygenation and static respiratory system compliance in COVID ‑ 19 ARDS vs . non ‑ COVID ARDS. Respiratory Research, 1–12. https://doi.org/10.1186/s12931-021-01819-4

Phua, J., Weng, L., Ling, L., Egi, M., Lim, C., Divatia, J. V., Shrestha, B. R., Arabi, Y. M., & Ng, J. (2020). Review Intensive care management of coronavirus disease 2019 (COVID-19): Challenges and recommendations. The Lancet Respiratory, 8(5), 506–517. https://doi.org/10.1016/S2213-2600(20)30161-2

Polit, D. F. (2018). Essentials of nursing research: Appraising evidence for nursing practice (Seventh Ed). Wolters Kluwer Health Lippincott Williams & Wilkins.

Qayyum, U., Akhtar, N., Nisar, S., Qayyum, A., Hussain, A., & Kashif, A. S. (2022). Effect of prone positioning as modality for improvement in bedside oxygen saturation in awake non-intubated COVID-19 patients and its relationship with high resolution ct chest severity score. Pak Armed Forces Med Ical Journal, 72(1), 223–226. https://doi.org/https://doi.org/10.51253/pafmj.v72i1.5920

Sartini, C., Tresoldi, M., Scarpellini, P., April, P., & Scientific, R. (2020). Respiratory parameters in patients with Covid-19 after using noninvasive ventilation in the prone position outside the intensive care unit. The Journal of the American Medical Association, 323(22), 2338–2340. https://doi.org/10.1001/jama.2020.7861

Singer, B. D., Chen, J., & Koyama, T. (2023). Predictive value of the ROX index and hypoxemia markers in early COVID-19 respiratory failure. Chest, 164(3), 512–523.

Society of Critical Care Medicine (SCCM). (2023). Clinical guidelines for prone positioning in ARDS. SCCM Official Guideline Update 2023.

Solverson, K., Weatherald, J., & Parhar, K. K. S. (2021). Tolerability and safety of awake prone positioning COVID-19 patients with severe hypoxemic respiratory failure. Canadian Journal of Anesthesia/Journal Canadien d’anesthésie, 68(1), 64–70. https://doi.org/10.1007/s12630-020-01787-1

Sryma, P. B., Mittal, S., Mohan, A., Madan, K., Tiwari, P., Bhatnagar, S., & Trikha, A. (2021). Effect of proning in patients with COVID ‑ 19 acute hypoxemic respiratory failure receiving noninvasive oxygen therapy. Lung India, 38((Suppl1):p S6-S10), 6–10. https://doi.org/10.4103/lungindia.lungindia_794_20

WHO. (2020). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 ( COVID-19 ) (Issues 16-24 February 2020). Retrieved 03 December 2025 https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf

Yang, P.-R., Tsai, Y.-T., Tsai, H.-Y., & Chang, G.-H. (2024). Effects of sitting, supine, and prone postures on nasal patency in individuals with obstructive sleep apnea syndrome. BMC Pulmonary Medicine, 24, 445. https://doi.org/10.1186/s12890-024-03278-1

Yarahmadi, S., Ebrahimzadeh, F., Mohamadipour, F., Cheraghian, T., & Eskini, M. (2023). Effect of prone position on clinical outcomes of nonintubated patients with COVID-19: A randomised clinical trial. Collegian, 30(3), 449–456. https://doi.org/https://doi.org/10.1016/j.colegn.2022.12.005

Zhu, W., Zhang, J., Yang, Y. & Li, J. (2024). Competency in responding to infectious disease outbreaks among nurses in primary healthcare institutions: A quantitative, cross-sectional multicentre study. Frontiers in Publich Health, 12:1406400. https://doi.org/10.3389/fpubh.2024.1406400

Most read articles by the same author(s)